It has been asserted that growth factors have a large molecular size that prevents them from entering the epidermis. However, several clinical studies, over the past 15 years, have highlighted the benefits of topically applied growth factor products showing improvements in the appearance of fine lines, wrinkles, texture, and discolouration.
Combinations of growth factors with antioxidants eg, vitamin C and peptides eg, cytokines tend to show results sooner, typically within 4—8 weeks.
It has been hypothesised that when growth factors are applied to the skin in high concentrations, a small fraction penetrates the superficial epidermis, and initiates a communication chain that leads to stimulation of dermal fibroblasts to produce collagen. Growth factors used in conjunction with needling , laser resurfacing , fractional resurfacing or injection are more effective than when used in creams alone.
Advances in biotechnology over the past decade have created multiple sources of growth factors. However, fat stem cells are likely to produce growth factors that help the functioning of fat cells, and bone marrow stem cells are likely to produce growth factors that improve the functioning of the bone marrow.
In a comparative study published in dermal growth factors outperformed growth factors derived from other kinds of human stem cells, like fat cells, as well as non-human sources of stem cells, such as snails and plants. Topical skin creams containing endogenous growth factors are used as cosmeceuticals. Skin creams containing a physiologically balanced mixture of growth factors and other proteins are available to reverse the signs and symptoms of:. In extrinsic skin ageing , external factors are responsible for the signs of ageing, particularly ultraviolet radiation due to sun exposure and tobacco smoke.
Extrinsic factors cause degradation of collagen and other factors leading to:. Controlled clinical studies have shown that the application of skin creams containing growth factors:. Protecting newly rejuvenated skin is essential in maintaining results.
Free radicals produced by sun exposure, smoking, and pollution can damage skin rapidly, negating any benefits of growth factors. Antioxidants, such as Vitamin C, neutralize free radicals and provide an extra layer of protection beyond sunscreen alone. For more serious skin concerns, Vitamin A retinol may be added to the regimen with growth factor products.
Retinol works slightly differently than growth factors so the combination would provide a better outcome than either one alone. Talk to your skin care provider about a complete regimen that is right for you.
Clinical results show that growth factor products benefit anyone with visible signs of facial aging. While women with early signs of aging may benefit by using growth factors, most significant visible improvements in skin are seen in women with greater photodamage and mature skin.
Twice a day use with diligence is the key to maximizing benefits from growth factors products. Your skin care professional can advise whether or not products containing growth factors are right for you. Talk to your skin care provider about a routine that is right for you. Growth factor skin care benefits anyone with visible signs of facial aging.
While women with early signs of aging may benefit by using growth factors, the greatest visible improvements are seen in women with greater damage and mature skin.
Dedicated, twice-a-day use is the key to maximizing the benefits from growth factors products. Your skin care professional can help you learn whether or not products containing growth factors are right for you. The content for this blog was provided by Rahul C. Rahul C. He is a pharmacist by training with over 30 years of experience in pharmaceutical research and development.
He has authored or co-authored over 50 research publications and book chapters, over poster presentations and multiple patents in pharmaceutical sciences.
Mehta is strongly committed to bringing pharmaceutical level evidence-based skin care with strong biology and clinical science for creation of multi-modality holistic skin care products. Where do Growth Factors in skin care products come from? They order others to repair broken skin. You get the drill. Now, your skin can do this on its own. But as you grow old, the levels of growth factors start to decline. Struggling to put together an anti-aging skincare routine that really reduces the look of wrinkles and gives your skin a youthful glow?
As a group, growth factors make aging and damaged skin look better. Individually, each growth factor has its own specific job to do. Here are a few examples:.
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